@alobpreis If you want to try and fix your existing profile, here are some things you can try:
Goto the URL opera://about, take note of the "cache" path, close Opera and delete the "Cache" and "System Cache" folders in the cache path to see if that helps.
If that doesn't help:
Goto the URL opera://about, takte note of the "profile" path, close Opera and delete all folders with "Cache" somehwere in their names. Then, go up one folder level (where you can see the "Default" folder) and delete all folders there with "Cache" somewhere in their names.
If you're not using Opera Sync, you can try:
In both "C:\Users\yourusername\AppData\Roaming\Opera Software" and "C:\Users\yourusername\AppData\Local\Opera Software", while Opera is closed, make a copy of the "Opera GX Stable" folder named "Opera GX Stable Backup". Then, you can try deleting things one by one and testing to see what makes Netflix work again. For example, you can delete the "History" file to see if it helps. You can delete the "Cookies" file in the "Network" folder to see if it helps. You can delete the "File System" folder to see if it helps. you can delete the "Local Storage" folder to see if it helps. You can delete the "IndexedDB" folder to see if it helps. You can delete the all the folders with "Extension" in their names and also delete any "IndexedDB" folders that start with "chrome-extension". You can delete the "WidevineCDM" folder to see if it helps. You'll have to goto the URL opera://components, update Widevine and restart Opera afterwards first though.
You can delete the "Preferences" file to see if that helps. If so, you can delete the "Opera GX Stable" folders, make copies of the "Opera GX Stable backup" folders and rename them to "Opera GX Stable". Then, you can open the "Preferences" file in JSONedit in tree mode and see if it you can see a specific setting that you think might be causing the issue and remove it and save your changes.
You can delete the "Local State" file or the "Secure Preferences" file.
If you play around enough, you might eventually find the culprit file, which might narrow things down for the Opera devs.