Try disabling Opera Sync.
More and more people are reporting this lately.
All my Opera Desktop installations (Linux, Windows) are having this problem for more than a month now (since Opera 45). A new profile didn't work.
In new version I've got something like "speeddial.ini".
This is an Opera Presto (Opera 12.17 and older) file. You can't convert Opera Blink bookmarks into Opera Presto ones, unless maybe by using extensions.
I played it from here and it was fine.
And from the D93 popup player at bottom of link for Tunein Radio
Maybew it will play better for you out of TuneIn Radio. It's one of their stations. You could register with them (they have tons of stations) and see if it makes a difference. To be able to register, I think you'll have to disable any ad blocker, or you may have, or whitelist the site from your adblocker.
I can't figure out why you're having a problem. You're have more ram than I do. I'm not sure about the rest but it sounds good. Do you by any chance have Off-Road mode on with Opera 21. If so, that might be causing a problem. It prevented me -- when I had it on -- from playing Pandora. I was able to play your station, but you might want to check it. Make sure Off-Road mode is off. Also, I'm assuming you got your Flash update IN the Opera browser. In other words, WITH Opera 21 you went to the website for it.. If not, take Opera 21 to the site and try downloading and installing again. It can't hurt