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@Gee-B One request per topic please
If you can figure out how to launch the Opera app with the --user-data-dir=pathtofolderyouwant command-line switch, you can create a script or shortcut for each profile you want. See https://www.reddit.com/r/operabrowser/wiki/opera/new_profile/#wiki_create_multiple_profiles_for_opera for examples for Windows to get the idea. Then, see https://forums.opera.com/post/369720 and the comments that follow for some ideas how to do that on macOS.
