I have this problem for years, and never find a solution, so I use Firefox...
Some fonts (Arial, Verdana and classic fonts) are more bold and blurry in Chromium based browsers.
Look at the image:
And it's worst on screen than on the image because the whole pages seem bold, it's ugly.
Yes I have checked Windows "don't adjust to high DPI screen", also have tried old Windows compatibility modes,
yes I have run Opera with --disable-directwrite-for-ui
yes I have uncheck Cleartype in Windows...
No problem with the old Opera 12, or IE, only Blink/Chromium.