Some website always open one pop-up when you first click anywhere on the page, e.g., www.netvasco.com.br. I visit that website a lot and I know they have this ad that pops every first click
Well, this topic is about YouTube ads so ads in any other page are unrelated stuff.
Also, pop-ups has nothing to do with adblocker. Opera has a pop-up blocker too.
Blocking pop-ups may not be that easy, specially those triggered by clicks.