I am having the same issues with Opera and the flash version 220.127.116.11 did system restore takes me back to previous flash 18.104.22.168. all seems fine on the 22 version. Make sure you don't have it set to auto update to the latest version though, otherwise it will re-install 22.214.171.124.
Thank you Tom Marshall, the information you gave me to fix my PPAPI Flash worked and i have no problems now !!! You RAWK !!!