Fixed in 118.0.5461.60.
https://blogs.opera.com/desktop/2025/04/opera-118-0-5461-60-stable-update/
It works fine for me now.
Best posts made by ss9227
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RE: [Solved]"Block third-party cookies" option under "Third-party cookies" is no longer selectableOpera for Windows
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RE: The favicons of all the sites are whiteAppearance
I can see nothing about it in changelog, but for me issue disappears of 120.0.5543.128.
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RE: All websites regularly loose permissionsGeneral
I've got the same problem! I noticed this because I've blocked notifications and only grant permission manually to certain websites. But after a while - a few hours or a few restarts - those websites suddenly no longer have permission... It's so annoying! Camera and microphone permissions behave in exactly the same way, but I use those much less often, so it doesn't bother me as much. However, I can confirm that this problem does exist.
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RE: All websites regularly loose permissionsGeneral
"Automatically remove permissions from unused sites" is disabled.
I don't clear "site settings" (on exit) and Opera don't allow me to enable it coz I have sync on.
AppData Roaming and Local:- "click the read only box to clear it": didn't help,
- "Security" tab: it's everything fine there.
"Reset passphrase": I done it, additionally I turned off "Settings" sync this time: didn't help.
"System -> Notifications" it's everything fine there... Notifications works as long as Opera doesn't remove them.
CCleaner etc - I don't use apps like that.
Standalone installation / completely fresh profile - I might test this out if I find the time, but like @MichaIng wrote, I'm afraid the problem will return and my efforts will go to waste

I use installed and synced instance but I se here are users with portable and logged out instalation and have the same problem.
And as I wrote previously - this also applies to camera and microphone permissions, but I use notifications every day and I notice their absence immediately. So I specifically gave cam+mic permissions to some website fot test and they disappeared exactly when the notifications also disappeared. It took about 7 hours.