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@silverfox66 They are out of sync, so you need the libffmpeg.o from version 70.
I found the old file under /var/cache/apt/archives - chromium-codecs-ffmpeg-extra_70.0.3538.77-0ubuntu0.16.04.1_amd64.deb.
I extracted the libffmpeg.so file from there and put it in the Opera directory (/usr/lib/x86_64-linux-gnu/opera/).
I had this working with Linux Mint 18.3
Could it be a new update that I installed yesterday - package file is chromium-codecs-ffmpeg-extra_64.0.3282.119-0ubuntu0.16.04.1_amd64.deb? (There was a new version of Chromium as well.)
I am using Opera version 50.0.2762.67.