I've noticed a pretty large slow-down the last couple days too and a lot of Flash problems. Checking Windows Task Manager I see a lot of memory being dedicated to Opera.exe, dpi settings, disable direct npapi requests, enable deferred image decoding. I know NPAPI is becoming less and less supported and PPAPI being the way to go, I sort of suspect this has something to do with it. 454,000K is being dedicated to these various "disable NPAPI requests" processes, that strikes me as a touch extreme.