My Dell computer that doesn't have the Creator Update worked with the "hardware acceleration" turned on, but I just did "About Opera" today and it updated to version 44.0.2510.1218 (PGO) and now "hardware acceleration" has to be turned off
for VPN and Ad Blocker to work (I also turned off the 3 Extensions to make sure that wasn't the problem).
I'm Microsoft and Cisco Certified so yes I know what I'm doing 
This is a Opera/Chromium Problem
Version information
Version: 44.0.2510.1218 (PGO) - Opera is up to date
Update stream: Stable
System: Windows 10 64-bit
Browser identification
Mozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/57.0.2987.133 Safari/537.36 OPR/44.0.2510.1218
Like I said my Dell 64bit without the Creator Update worked fine until I updated Opera to the newest version
So this is telling me there is a coding bug in this new Opera update
This computer I'm on now like I said above does have the Creator Update
Thank you and Opera Please fix this problem