I am not going to start another thread because I also experience these problems. My brother and I on separate computers both have encountered the same problem. It started today with Google sending old format pages sometimes and I updated it (there was a new patch available) and now the problem is even more extreme with normally formatted Google pages not even appearing. This is also the case with the Google.ca homepage as operauser12356 stated. I cleared my history and caches on google and even removed every single extension I had installed (even if they were not enabled). I have a fast internet connection I strongly doubt the connectivity has anything to do with it. My brother is also on ethernet and even faster internet but still the same problem.
I have no VPNs enabled (I never even really used them). Internet Explorer works fine with Google (I am on Windows 7). My brother is on Windows 10 and his Edge works fine as well. It appears to just be Opera. My version of Opera is 45.0.2552.812 (PGO) and although I can't confirm I think my brothers may also be the same one. I also do not have any proxies on as far as I am aware. It also does not matter if Opera Turbo is on or not. This problem still occurs.
I ran a malwarebytes scan and it did not pick up anything relating to Opera. I still have to run HitmanPro and verify Malwarebytes did not miss anything though. I disabled both Malwarebytes and Kasperky (my main anti-virus) and the problem still persists. I'd like to hope it isn't malware but right now I have no proof it is or isn't. I believe it could be something with Opera (the ammount of people getting this issue are making me suspicious) but that is all I have to go off of.
I have yet to do a clean and full uninstall and reinstall to see if it continues there and I am going to try an earlier version of Opera but am unable to do so right now.