@wembley1488 Thats weird you have enable it Everytime.. maybe reinstall it. I also use opera gx and my settings are: Under site access it's ://www.youtube.com/ and I have allow incognito. I have a backup of my settings for the add-on, if all else fails maybe import it?
Here. The extension icon is always lit up for me.

Amazing Extension, no more ads!
Works seamlessly, highly customizable
love cinema mode feature.
I don't have to go into fullscreen. when I click out of it I don't have scroll down to get rid of search bar and youtube taking up part of my video.