@r4t I can identify with this. It started when Windows 10 updated in April and Opera had an update around about the same time. I cannot tell which update is the problem (I have a tendency to think it's Windows 10) but it expresses itself as the mouse refusing to work on the Windows Task Bar and on the Opera Tab bar.
In other words windows explorer.exe crashes.
I don't know if this is the same issue you have (I have an AMD board too)
All I have to do to fix my problem is cntrl-alt+delete and cancel out of the menu and the mouse works (I don't have to open task manager or restart windows explorer.exe). It just starts working by itself.
I was experiencing sluggishness of Opera timing out on sites a lot but (ironically), that same April Windows 10 update seems to have fixed that particular issue.
Since that April Windows 10 update, I have noticed very delayed responses from my machine particularly when coming out of sleep or a restart.
I will never buy AMD again. There seem to be too many Windows 10 problems with AMD boards.