I have the same problem. On many web sites, but not all, the browser does not respond to clicking the hyperlinks near the bottom of the screen. But it does appear to allow text selection. One of those sites is YouTube. Can't expand the comment section. Other browsers work fine. I wonder if it has something to do with my screen shape which is a large screen that is tall and slim. If it weren't for opera's other great features I would have ditched this browser by now.

Opera 52.4.2517.140781
Android 9
OnePlus 7 pro