OK, still the same. Cannot Update. But it is a Win 7 PC. If I uninstall the older version, reboot and then reinstall the new version I have the new version. But the Auto-Update still fails. Yet, Chrome and FF update fine. Even Windows updates fine. It is ONLY Opera. Anyone have any other ideas? I am open.

Thank you. Let me explain. The machine has NO AV or Firewall. No Wi Fi, it is a bare bones machine.
It is wired into a router. The same connection updates Chrome, which is what Opera is based on. So its not the Firewall, and as to USB, why do that. I do not use USB.

No. I loaded the same Opera on a laptop and compared. It worked. The one on the desktop did not. Yet all other browsers are OK with updates. Something is blocking the Opera from updating on my desktop. Tried disabling each plug in. Same result, error. Not sure what else to do. Hopefully Opera developers can determine what it is.

BTW, this error was in 18, then 19, I uninstalled 19 and manually downloaded and upgrade to 21. Same error appears.

By "constantly" I cannot remember the last time it worked. Only this browser on this machine does this. Yet Chrome, FF, IE, will all update. There are no auto-update settings in this version of Opera.

I constantly get this error. I have uninstalled and reinstalled opera. All other browsers update fine. Chrome updates, Firefox Updates, IE updates, only with Opera do I get this error. And the help is sooo poor it keeps pointing me to auto-updates in settings and there is none.
To update I have to download and install a new version manually. This is not good. Any help to correct this is appreciated.
Right now I see Opera as a 1st class browser with 3rd class help and support.