@sgunhouse It turns out that I have the last version of Opera that I am allowed to have. I have several disability tools that I can't get for later operating systems.
So it seems that Opera / Lastpass are no longer compatible. Lastpass blame Opera and I suspect that Opera will blame Lastpass if they deign to answer.
I have not had any errors saying it is not supported, I have uninstalled and re-installed.
I am not sure if there is a way to further rollback Lastpass, I think it installs the latest version it can work with Version 4.133.0 rather than Version 4.4.