Firstly, you need to confirm when exactly the mouse stops working. For that, you need to use click test (https://cpstest.pro). Close All opera instances and try clicking on the test. Then Opera and try clicking again. See when does your mouse clicking exactly. If Opera seems to be an issue, open Opera, go to Settings and reset all settings. Now check the mouse again and your issue should be resolved.
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RE: Opera freezes my mouse, mouse suddenly stops working until I close every running Opera instanceOpera for computers