I have exactly the same issue and the above suggestions don't seem to have fixed it. No problems until I upgraded to 12.17 an hour ago. Now the keyboard (built in laptop keyboard) does not work at all in Opera, but works fine in everything else. I then downloaded a fresh copy of Opera USB 12.16 and opened it from a separate location, but had the same issue in it. I have used Opera USB for years. Any more suggestions are welcome..
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