Does the issue happens even with sync disabled?

No! Only with enabled sync)

Did you check with a clean profile folder?

Yes, i've deleted opera and all data.

No idea? )

Hi! I have the same problem on different computers!!! I tried to instal opera beta\stable\developer but it's not help me.
I found out that it happens when opera tries to synchonize my opera account. I clear this folder c:\Users\username\AppData\Roaming\Opera Software\Opera Stable\Sync Data\ and deactivate synchronization and now opera work good. But synch. is realy useful thing...

The latest versions of Opera Beta and Opera Stable crashes after I synchronize my account.
Opera tries to restart 3 times and 3 times crashes.
Windows 10x64.
Maybe you have any solutions? )