This only occurs on 64-bit Windows 10, not Windows 7, 64- or 32-bit, suggesting that Opera 46.0 is not 100% compatible with Windows 10 64-bit.
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I have a fresh installation of Opera 46.0 on a computer which has never had any previous version of Opera installed. However, when trying to add extensions I receive the following error message:
An error occurred when installing the extension: Installation failed