I'm running the latest version of Opera (ver 48) and installed the following W10 update this morning;
2017-10 Cumulative Update for Windows 10 Version 1703 for x64-based Systems (KB4041676)
The result was a crippled Opera installation with most of the files removed from the Opera directory, but not deleted to Recycle Bin.
It appears the W10 update is directly responsible as I have not made any other changes to my installation.
Thought you should know.