I am not sure why Opera has crashed on me a few times in the past 2 weeks. It could be due to internet connection problems. The program should not be bothered if the internet connection suddenly drops, but it may cause enough problems to crash it.
Regardless of cause, I think I may have found a possible way to avoid the "error, can't open user profile directory..."
When Opera has crashed/ not responding, try to close it with Windows Task Manager. Try to close the program under applications, and then try to close all processes that say "Opera" under processes. I think if all these processes are ended, the weird problem will not happen when you try to open Opera again.