I have the same problem. windows10, windows defender. It happens every day. After it happend, I restart windows, so opera works for some time. Alternatively I use edge that doesn't claim any memory problem.
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RE: new version - OUT OF MEMORY issueOpera for Windows
RE: Permanente Fehlermeldung: Speichermangel! Habe aber genug... was tun?Deutsch
Ich habe das gleiche Problem, habe aber weder Ad-Aware noch Comodo oder Bitdefender. Habe Windows10.