Same problem since 42.0.2393.94 update. OUT OF MEMORY errors; reload does not work;
Windows 10 64-bit (WoW64)
8gb ram
GeForce GT 630 graphic card
AMD Athlon II x4 645 processor
Avira antivirus
using VPN
I turned off hardware acceleration setting
I use lots of extensions: download chrome, one tab, forever pinned, pocket, disconnect, https everywhere, ublock origin, grammerly
I've used opera as my main desktop browser for over 15 years...