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Not sure it's hardware related. It's happening on my HP Z1 workstation running Win 7 as well as my Lenovo X1 Carbon running Win 10. I used to think it was only happening with a particular website I visit regularly (The NIH Pubmed database of research paper), but seems to be happening on other sites too.
Seeing the same issue with the last three releases of Opera (currently on 50.0.2762.67). Opera crashes with CTRL+TAB or SHIFT+CTRL+TAB. Hope a solution is found soon. A clean install (complete uninstall + remove profile etc. + reinstall) solved the issue, but just for 2 days and the issue is back again. Clean install doesn't appear to be a permanent solution.
Same problem - small fonts throughout and changing font size screws up most webpages. Using HP Z1 at default 2560x1440 resolution. Similar issues on my HP 4330 laptop as well.
Strangely, the fonts in the drop-down menu from the top left and the tool tips are OK (ie. larger, like before the update), but fonts on address bar, tab names, webpages etc have shrunk.