@leocg It launches as it should, with the original profile. It does not with the second one (called profile 1 in my example).

@leocg Yes, the new launch string is:
"C:\Users\Paul Vern\AppData\Local\Programs\Opera\opera.exe" --user-data-dir=C:\Users\Paul Vern\Downloads\Opera Profiles\profile 1"

I've tried also
"C:\Users\Paul Vern\AppData\Local\Programs\Opera\launcher.exe" --user-data-dir=C:\Users\Paul Vern\Downloads\Opera Profiles\profile 1"

Both of them don't work with a message saying that the privileges are not enough to access the profile. I've tried also launching it as administrator but it seems that's not the problem.

@leocg Sure

Hi there, I noticed that the flag opera://flags/#side-profiles is still there but it seems it does nothing. I didn't find any way to have multiple profiles. It seems even having a different launcher doesn't work with opera one. Any idea?