I have been using OperaGX for years, and I started having the same problem just a month ago. It will work for 5 or 10 minutes, then no new pages will load. if I am on youtube with autoplay on, it will continue playing videos.
Chrome or firefox work fine. I'm sad to have to quit OperaGX.
Nothing fixes it. I reinstalled 3 -4 times, reverted back to original settings, deleted all extensions, flushed dns, tried switching off hardware acceleration, vpn, etc...