I have experienced this problem more than once in the past, and I am now experiencing it again.
About 3 days ago I was listening to music on MixCloud.com through opera, as I have been for years. Opera is my main browser, though I use many others as well. Suddenly the music stopped. it shows as playing, but no sounds are emitted.
I receive my usual email notification sounds from Outlook. I opened Chrome to the same site, works fine.
I accessed the Windows 10 Volume Mixer which can have app-specific audio controls, no problems there.
The Opera "Additional Content Settings - Sound" -> nothing restrictive there.
I've explored all the possibilities mentioned in this thread. Nothing.
My opera://media-internals display looks identical to that of john-phd, with AudioServiceLaunchOnStartup = "Disabled" whatever that implies.
It's pretty weird that one day I'm booming along then whammo, Opera is silent with nothing to correct it.
I like Opera, but I gotta admit that I'm tempted to shift over to Brave as my primary browser, merely because it's working and I can just reopen my 110 tabs there and be off and running again. I haven't seen any real solutions on the web pertaining to this reoccuring problem. sad face.