I've seen enough ads/promotions that I though I would finally try out Opera GX. While it has a great interface, and some awesome features I find that it uses about 1.5x to 2x the amount of RAM as Chrome. (Tested on multiple websites, mainly YouTube)
I'm currently running with only 32gb of RAM and like to keep it low as possible. I would suggest trying to minimize RAM usage and I may consider trying it again. Until then I'm going back to Chrome.