https://forums.opera.com/topic/87088/how-to-fix-opera-gx-grey-black-white-empty-screen-on-startup/2
Have a look here, this fix works for me 
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https://forums.opera.com/topic/87088/how-to-fix-opera-gx-grey-black-white-empty-screen-on-startup/2
Have a look here, this fix works for me 
@leocg Same issue here, using Opera One on Windows.
Reinstalling, uninstalling etc. didnt help.
Worked when I started the PC, then I pressed the update button in Opera. Afterwards just grey screen.