Windows 10 1803 (17134.345) x64
Opera 56.0.3051.43
As the title says, when attempting to reload a web page without using CTRL+F5 or SHIFT+F5, Opera still uses the disk cache for items. The only way to do so is to open the developer's tools, select "Disable cache" on the Network tab, and then reloading. I have verified that the shortcuts are set in settings.