I am also having the problem with error 0xC0000022 with the update Opera_GX_63.0.3368.57756_Setup_x64.exe on Windows 10 Pro. I have tried the suggested fixes in the link leocg provided. That did not help.
As much as I like the concept of the browser (resource management), I will re-visit the browser in 6 months or so after they get some teething problems fixed.