@donq
Gotcha. I gave Opera all the security access through it's properties, and my virus software (Webroot) hasn't ever had issues with it before.
I can't see anything too relevant in the event viewer, and the process monitor information that comes up when I try to open the browser is mostly a mix of "Success","Name Not Found", sometimes "Reparse" and an occasional "Buffer Too Small". I'm...not really sure if any of that is helpful though.
I removed the temp files and ran "chkdsk /f /r C:" in the command prompt to clean things out. After restarting I was able to open it, but no pages would open and eventually when I closed out and tried reopening it the error came back up.
I appreciate your help. I am a bit of a novice at this stuff. I'll keep trying to figure it out.