Yes, it’s possible to use a YubiKey 5C NFC with Opera, but support can vary depending on how the website and Opera handle WebAuthn (passkey/FIDO2) authentication. Opera is Chromium-based, so in most cases it should work similarly to Edge or Chrome — as long as your YubiKey is set up correctly and the site supports standard WebAuthn protocols.

However, some users have reported limited compatibility in older Opera builds. I’d recommend updating to the latest Opera version (Developer or Stable) to ensure full WebAuthn and passkey support. Also, make sure that Windows Hello and security key support are enabled in your Windows settings.

If it still doesn’t work, try switching temporarily to Chrome or Edge to confirm your key’s configuration, then return to Opera once it’s fully updated. The Opera team is actively improving passkey and hardware authentication support, so updates should continue to make this smoother.