My colors in-browser have become very saturated, and I had to enable #force-color-profile to Display P3 to get pages to look normal.

sRGB flag made no change.
Normal meaning colors like Chrome 97.0.4692.71.

In terms of troubleshooting nothing in system and setup had changed prior.

WIN10-64. Opera 82.0.4227.43 Stable. HWA on. WIN HD Color off.

No flags besides those mentioned above. No relevant extensions active.